When advertising a product for an affiliate program via Adwords, nutritional supplements for example, then make sure you are targeting your campaign correctly.
For the purpose of this example you would need to know that different countries have different legal issues with respect to supplement importation. There is no point spending your money advertising to people in countries that won't be able to place an order.
Another issue to consider is shipping. Some companies offer absolutely horrid shipping terms to foreign customers. If you spend your Adwords dollars promoting such affiliate programs you'll find the conversion ratio is almost non-existant. This is because even if you did find an interested party, they'd get frustrated by the shipping costs or terms, and abandon their purchase during the checkout process.
Personally, what I have noticed is that if I target my advertising worldwide I'll get a lot of foreign clicks, but those clicks are very unproductive. I generally target my Adwords campaigns at US consumers only unless I have a specific reason to expand my reach. Until you develop some expertise you'd be wise to do the same yourself. If foreign consumers can easily buy the product or service you promote then you may find you can advertise to them at a cheaper price. However, do keep in mind that consumers in some less developed countries will simply be unable to afford the products you selling.
To summarize, before spending money to advertise outside of your country you must first consider various issues. These include legal issues, shipping particulars, and the basic disposable income level of your prospective customers. If you have considered these and other applicable issues, such as language, then you may find it profitable to do business on a wider scale. Start small and expand your efforts if you find that they are successful.
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