With the development of modern biotechnology, biological treatment has become increasingly important, docetaxel as pharmaceutical raw materials, being used to treat advanced lung cancer are gradually increased. However, at present, about the simple allergic reactions reports of docetaxel is less, doctors is not enough understanding of drug adverse reactions.
Docetaxel supplier thought that through nursing simple allergy sufferers caused by docetaxel to find good rash care of patients is very important. Patients, if show up allergic skin rashes, medical staff should be prepared to do psychological, skin and diet care, at the same time adjust the body state, enhance the body resistance, make patients treating according to the course, to ensure the treatment effect.
A 48-year-old male patient was diagnosed as a right lung papillary adenocarcinoma and alveolar cell carcinoma. The head multi-enhanced scan intracranial metastases, given the whole brain radiotherapy 20 times, meantime line the bisphosphonates treatment of bone metastases. Reviw a month ago found that the intrapulmonary tumors bigger than the previous, given docetaxel single-agent week regimen of three weeks. Chemotherapy regimen of 250 ml of 5% dextrose injection and docetaxel 40 mg, intravenous injection.
Patients’ chemotherapy process is smoothly. Patients on the same day in 9:00 carry on the fourth week docetaxel single-agent chemotherapy, at 11:00 the right hand back swelling, mild pain given chemotherapy extravasation process immediately, namely the partial closure (10ml saline plus dexamethasone 5mg plus lidocaine 5ml), sustained cold apply. At 4:00pm, the patients’ hand back swelling disappeared, no pain; next day, the hand back skin restore normal skin color, private prosecution no local discomfort. After one week, the patient’s hand back suddenly swelling, pain extends to the upper limbs, large areas of erythema, given the partial closure immediately, cold apply; next day give dexamethasone 10 mg plus lidocaine 5 ml plus gentamicin 80,000 units plus Yunnanbaiyao 10g mixed into a paste partial to apply, the microwave hyperthermia irradiation for 30 minutes. Through four consecutive days of treatment, the patient's symptoms gradually reduced until it disappears, the back of the hand excoriation, local skin more red than normal skin.
In this allergy, the skin of patients have locally severe pain, unbearable, large areas of erythema, three days after show up the exfoliative dermatitis change, thin epidermis easy ulceration. The care medical personnel should tell patients not scratching the skin, do not use hot water rinse injured skin; cold apply three times a day, every time 30 minutes; avoid the sun to stimulate the skin. Patient with itching, use saline cold compresses or with anti-itch cream rubbed; accompanied by blisters, under aseptic operating with a sterile syringe reuse withdrawn the liquid in blister then use bubble film paste bandage, changed 1 times every other day. Give patients high-protein diet, high energy, high vitamins, digestible semi-liquid diet, encouraged patients to drink more water, accelerate the excretion of toxic substances, eating more green leafy vegetables, fruits, don’t eat spicy, seafood, irritating food, don’t eat foods with high sugar content, so as not to increase the sensitization factors, aggravate the symptoms. If feel pain in nighttime, tell patients taking phenol A coffee powder (headache powder) at bedtime, 1 packet at a time, so that can ease the pain, and good for sleeping.
Source:http://www.cospcn.com
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