A mixed herb PHY906 can reduce the gastrointestinal toxicity damage from cancer chemotherapy. This study emphasizes the value of traditional herbal treatment and explains the possible therapeutic mechanisms.
Toxic side effects of anticancer drugs resveratrol is a major factor to limit Iraq irinotecan effective use, because serious side effects affecting the quality of life. Irinotecan is a DNA-isomerase inhibitor, is the second-line drugs for the treatment of colon and rectal cancer, PHY906 of mixed herbs in the effect of reducing the gastrointestinal toxicity caused by irinotecan. Diarrhea and nausea are common side effects of irinotecan, resulting in taking the drug also ulcers and intestinal bleeding, because it will lead to intestinal cell death and inflammation. However, the ways to control these toxic side effects limit the efficacy of the play.
PHY906 from on one for the treatment of nausea, vomiting and diarrhea, an ancient Chinese herbal formula composed of four kinds of herbs, their quality of stability control. Now, when will be the PHY906 used to take patients with irinotecan, which can reduce the patients with diarrhea and vomiting.
In order to study the reasons for PHY906 ease irinotecan lead to intestinal damage, Yale University School of Medicine used a colorectal cancer model in mice. Irinotecan conga PHY906 such tumors in mice 4 days of treatment, results showed that PHY906 alone can inhibit tumor growth, but it can stimulate the activity of irinotecan antitumor, and mitigation and drugs in treatment-related weight loss. In addition, PHY906 promote recovery and regeneration of the intestinal cells by the injury of irinotecan.
Further studies have shown that PHY906 can not prevent irinotecan in the intestinal cells caused by DNA damage, but it can reduce the number of apoptosis, increased intestinal cell proliferation after treatment with irinotecan. Irinotecan Kang treatment PHY906 can promote intestinal progenitor source cell or stem cell marker expression, such as a cell surface transmembrane docetaxel glycoprotein CD44, rich in leucine repeat of the G-protein coupled receptor (LGRs) 5 and source chromosome 2 (ASCL2).
Regeneration was observed in the intestinal cells, Wnt signaling channel stimulation, because taking irinotecan after Kang the PHY906 increase the expression of key wnt components, such as Wnt3, FZD5 (frizzled 5) and low density lipoprotein by body-related protein 5. The study also showed that human embryonic liver cells, the PHY906 of treatment increased the activity of Wnt3A. The PHY906 inhibit irinotecan stimulate inflammation in several steps. PHY906 treatment blocked the infiltration of the intestinal neutrophils and macrophages reduced the expression of precursor cells in inflammatory cytokines such as tumor necrosis factor, etc.
Thus, although PHY906 can not directly protect the intestinal system from damage caused by chemotherapy, it does stimulate rehabilitation of intestinal cells through the promotion of rebirth of the ancestral source cell and the inhibition of inflammation. This study highlights the therapeutic value of traditional herbal medicine and illustrates the potential therapeutic mechanism which regulates various biological activities through the multi-herbal formula ingredients. It may be able to provide the efficacy that conventional medicines can not achieve.Source:http://www.cospcn.com
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