Application of retinoic acid in skin diseases

While the third revolution is the retinoic acid application. Retinoic acid is an intermediate product of vitamin A metabolism in human body. It plays an important role in the morphogenesis and differentiation of various tissues.

Retinoic acid according to the structure can be divided into three generations: the first generation is of non-aromatic retinoic acid. The representative drug is isoretinoic acid. The second generation is of the single aromatic tretinoin. The drug on behalf of them is avignon A. And the third generation is a multi-aromatic-dimensional formic acid, on behalf of drug, adapalene. There are many types of retinoic acid in the application, it was reported that retinoic acid can be used in dozens of skin treatment, described below In accordance with the principles of rational drug experience as well as safe, effective, economic, appropriate. The more common application of retinoic acid treatment of diseases: acne, psoriasis isometric resistance diseases, neoplastic diseases, seborrhea diseases.

Mild, moderate and severe acne, acne can be divided into according to the degree of skin damage, only different in the application of retinoic acid in the system has a good effect of retinoic acid on acne, psoriasis treatment drug of choice is acitretin, A Vitamin A better effect for erythrodermic and pustular psoriasis, the poor efficacy of the unusual and joint psoriasis requires combination therapy.

For the treatment of seborrhea disease, such as seborrheic dermatitis, seborrheic alopecia and rosacea, isotretinion will be selected for using. In other skin diseases such as cutaneous lupus erythematosus, lichen planus of retinoic acid treatment, sclerosing atrophic lichen, human papillomavirus (HPV) infection, sarcoidosis, scleroderma, granuloma annulare, people can use tretionin and astaxanthin.

The common adverse reactions of tretinoin are mainly dry mouth, cheilitis and dry skin. They are mostly transient. If stop withdrawal, it can be restored. Teratogenicity of retinoic acid is in need of special attention. All of retinoic acids have side effects. But time of different retinoid contraception is different. It is also noted that different retinoic acid in combination with tetracycline and doxycycline should be avoided so as not to cause brain pressure. It may results in the occurrence of false brain tumor. Typical clinical manifestations of retinoic acid syndrome are the fever, edema, hypotension, pulmonary infiltrate, pleural effusion, pericardial effusion, respiratory failure and renal failure, and resemble a severe lung infection and adult respiratory distress syndrome.Source:http://www.cosprm.com