The detoxification role of glutathione

Glutathione is now been widely recognized as a whitening ingredients in the international market, mainly by blocking the of tyrosinase synthesis of melanin pathway to inhibit melanin production, so as to achieve the whitening effect. Glutathione’s whitening effect is significant, in recent years it has also been widely used as cosmetics material.

Glutathione is a tripeptide combine of glutamic acid, cysteine and glycine, mercapto group-containing, has detoxification of anti-oxidation and integration. The mercapto group on the cysteine glutathione active group (glutathione often abbreviated as G-SH), easy has integrated detoxification with certain drugs (such as paracetamol), a toxin (such as free radicals, iodoacetic acid, mustard, The combination of lead, mercury, arsenic and other heavy metals). Therefore glutathione (especially glutathione in liver cells) can be involved in the biotransformation, and thus the machine body of harmful poisons into harmless substances, and excreted. Glutathione also helps to maintain normal immune system function.

Glutathione not only removes the body of free radicals, but also can improve the body's immune system. The glutathione in maintaining health, anti-aging, the efficacy of cells in slow elderly play better than the young. Glutathione also can protect the hemoglobin not to be oxidated by oxidation hydroxide radicals and other oxidation so that it continued normal functioning of the ability to transport oxygen. Part of hemoglobin in red blood cells under the action of hydrogen peroxide and other oxidants, the oxidation of ferrous iron to ferric iron to make hemoglobin into methemoglobin, losing the aerobic capacity. Glutathione can directly in combination with an oxidizing agent such as hydrogen peroxide, to generate water and oxidized glutathione, but also be able to methemoglobin reduction is hemoglobin. The content of glutathione in human erythrocyte is high, it has important implications for protecting the red blood cell membrane protein thiol in a reduced state and preventing hemolytic.

Glutathione to protect the enzyme molecules in the-SH group, is beneficial for the enzyme activity play its role, and can restore the activity of the-SH group which has been damaged by the enzyme molecule, to resume the enzyme activity. Glutathione can also inhibit ethanol against fatty liver. Glutathione a strong protective effect for the leukopenia symptoms caused by radiation, radioactive drugs. And enter the body of toxic compounds, heavy metal ions or carcinogen glutathione and promote excreted, play a role in detoxification.

The glutathione manufacturers remind that taking glutathione seldom show up nausea, vomiting and headache, rare rash. Glutathione couldn’t use in allergy, and shall not be used in combination with vitamin B12, menadione, Calcium Pantothenate, orotic acid, anti-histamine preparations, sulfa drugs and tetracycline and so on.

Source:http://www.cosprm.com

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ýSCcapsaicin manufacturer extract capsaicin: (1) extract from natural Pepper system, early capsaicin extract from dry red pepper, extraction with an organic solvent after crushing, and concentrated to give a dark red to orange red oily liquid. Ether extract color darker than ethanol extraction of color, a little sticky. This oil collectively called as capsicum oleoresin in the international market. Its main ingredient is capsaicin, dihydro-capsaicin, Are two dihydro capsaicin, high dihydropyridine capsaicin, capsanthin, carrot pigment, and citric acid, tartaric acid, malic acid, and other ingredients. Usually accounts for about 1% of the weight of dried fruit. The Oleoresin Capsicum through diethyl ether, dilute ethanol, and an aqueous alkaline solution, or concentrated further extracted with petroleum ether, dichloroethane, etc. solvent, crystallized from petroleum ether or n-oxide crystallization can be obtained crude capsaicin. Using gas chromatographic to analysis the crude capsaicin crystalline component. Which accounted for 76% -96% capsaicin and dihydro pepper alkali content. The researchers used high-concentration ethanol extraction capsanthin, a low concentration of ethanol extract of capsaicin. Capsaicin of 6% to 8% and 3% to 4% of capsanthin were extracted from the dried chili. First they use a low concentration of ethanol extracted from dried chili powder, pepper oleoresin capsaicin solution. The capsaicin solution was concentrated to give the crude product of capsaicin. The process is simple, low cost, the use of acetone, petroleum ether, 95% Ethanol capsicum oleoresin and the solvent as a result, and then ether to give the crude crystalline capsaicin, and purified by column chromatography on silica gel to give the pure product of capsaicin. Was also a direct high yield capsaicin extracted from fresh green chili. The fresh chilli powder pulverized frozen, and dried with acetone, ether, aqueous methanol, and an aqueous alkaline solution extract capsicum oleoresin, get a capsaicin crude in ether. Get pure capsaicin from Petroleum ether and recrystallized. Yield was 1.12% of the dried chili. (2) Preparation from biological cell cultivating. The capsaicin research in many countries was no longer satisfied with the system from natural pepper capsaicin, but use of a biological cell technology to produce more and faster capsaicin. Researchers from natural pepper meat-like body, the cells will be taken by its embedding and fixed, was suspended in 5 liters of an aqueous culture liquid, after 32 days the pepper alkali content is achieve a high degree, if extend the incubation time, chili alkali content will increase. (3) chemical synthesis methods take high purity capsaicin is very difficult due to the natural pepper have many analogues of capsaicin. People trying to get a successful synthetic capsaicin. Researchers use triphenylphosphine and 6 - bromo-acid as raw materials. Through four-step reaction, the synthesis of a sample of the extract obtained is identical to the pure capsaicin. The total yield is 26.6%.

Source:http://www.cospcn.com