In research that hints at new ways to tackle paralysis, a combination of drugs, electrical stimulation and "willpower-based training" prompted paralyzed rats to walk and even run.
In research that hints at new ways to tackle paralysis, a combination of drugs, electrical stimulation and "willpower-based training" prompted paralyzed rats to walk and even run. This combination of drugs includes Medrol 4mg tablets in several pharmacies.
"We expected that the rats would recover some degree of locomotor functions. We were, however, surprised about the extent of the recovery -- paralyzed rats were able to pass obstacles and run up stairs -- and the consistency with which we observed it," said study co-author Janine Heutschi, a doctoral student at the institute.
"Because the rats actively participate in the tasks, as opposed to automated movements, the brain is actively involved and is challenged to find new ways of controlling the hind limbs," she added. "Over time, new nerve connections are then formed."
"Over the past 20 years or so, research has moved away from getting damaged [nerve] pathways to work and trying to recruit other pathways to work -- to trick the spinal cord into creating a detour or other routes," explained Dr. Nathaniel Tindel, an attending orthopedic spinal surgeon at Lenox Hill Hospital in New York City. "That's the essence of this research. It's not groundbreaking in this sense, but what is unique is not that they got rats to move, but the techniques and protocol they used. This is great stuff because it's really delineating an approach for studying these new pathways."
Dr. Robert Grossman, chairman of neurosurgery at Methodist Neurological Institute in Houston, noted that the new study builds on a recently published case where a paralyzed young man regained standing and some voluntary leg movements after he was trained on a treadmill using electrical stimulation.
This new study is "a significant contribution to understanding the biological mechanisms underlying the generation of [movement] due to spinal cord injury," he said.
Heutschi said clinical trials to test the therapy on humans are being planned, though "we don't know yet what we can expect from studies with human patients."
But Tindel cautioned that the treatment methods used in this research aren't practical in humans because "rats have a phenomenal ability to regenerate, better than we do."
"It's a nice model because they can get results quicker," Tindel said, "but rats have a different system." Further studies are required to check if the experiment tested on rats will work on humans as well; and to buy Medrol online will work just fine for the meantime.
Paralysis is loss of muscle function for one or more muscles. Paralysis can be accompanied by a loss of feeling (sensory loss) in the affected area if there is sensory damage as well as motor. A study conducted by the Christopher & Dana Reeve Foundation, suggests that about 1 in 50 people have been diagnosed with paralysis.
Paralysis is most often caused by damage in the nervous system, especially the spinal cord. Other major causes are stroke, trauma with nerve injury, poliomyelitis, botulism, spina bifida, multiple sclerosis, and Guillain-Barré syndrome. Temporary paralysis occurs during REM sleep, and dysregulation of this system can lead to episodes of waking paralysis. Drugs that interfere with nerve function, such as curare, can also cause paralysis. There are many known causes for paralysis, and perhaps more yet to be discovered.
Paralysis can occur in localised or generalised forms, or it may follow a certain pattern. Most paralyses caused by nervous-system damage (i.e. spinal-cord injuries) are constant in nature; however, some forms of periodic paralysis, including sleep paralysis, are caused by other factors.
Ascending paralysis presents in the lower limbs before the upper limbs. It can be associated with:
· Guillain–Barré syndrome (another name for this condition is Landry's ascending paralysis)
· Tick paralysis
Ascending paralysis contrasts with descending paralysis, which occurs in conditions such as botulism.
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