Scientists study a mixed herbs named PHY906, can reduce the damage caused by gastrointestinal toxicity of cancer chemotherapy, this study emphasizes the value of traditional herbal treatment, explain the possible therapeutic mechanism.
The irinotecan price and the toxic side effects of anticancer drugs is a major factor limiting the efficient use of irinotecan, because of serious side effects affecting the quality of life.
According to pharmaceutical raw materials suppliers, Irinotecan is a DNA topoisomerase inhibitor, is the second-line drugs for the treatment of colon and rectal cancer, and now scientists reported a mixed herb called PHY906 in reducing the side effect of the gastrointestinal toxicity caused by irinotecan. Diarrhea and nausea are common side effects caused by irinotecan, taking this drug also show up ulcers within the intestinal bleeding, because it would lead to intestinal cell death and inflammation. However, the way to control these toxic side effects limit the play of its efficacy.
PHY906 from an ancient Chinese medicine formulations for the treatment of nausea, vomiting and diarrhea, is composed of 4 herbs, its quality by the stability control. Today, when PHY906 for patients taking irinotecan, it can reduce the patients with diarrhea and vomiting. In order to study the PHY906 remission Irinotecan cause intestinal damage, the researchers used a colorectal cancer model mice. 4 days of treatment with irinotecan conga PHY906 of such tumors in mice, found that PHY906 alone can inhibit tumor growth, but it can stimulate the irinotecan anti-tumor activity, and can ease this kinds of medication related weight loss. In addition, PHY906 promote the recovery and regeneration of the intestinal cells by the injury of irinotecan.
Further studies have shown that, despite the PHY906 could not prevent DNA damage caused by irinotecan in intestinal cells, but it can reduce the number of apoptosis, increased intestinal cell proliferation after irinotecan therapy. After irinotecan treatment, PHY906 can promote intestinal progenitor-derived cells or the expression of stem cell markers, such as cell surface transmembrane glycoprotein CD44 leucine repeat-rich G-protein coupled receptors (LGRs) and homologous chromosome 2 (ASCL2).
In the observed regeneration of intestinal cells, the signal path is also subjected to a stimulus, because of after taking irinotecan, PHY906 increased expression of key extracellular factor component, such as Wnt3, select FZD5 ( Frizzled 5) and low-density lipoprotein receptor-related protein 5. The study about human embryonic liver cells also showed that PHY906 treatment increased Wnt3A activity. Finally, the researchers also noted that, PHY906 inhibit several steps that irinotecan stimulate inflammation. PHY906 therapeutic blocking enteral neutrophil and macrophage infiltration, reduce the expression of proinflammatory cytokines such as tumor necrosis factor, etc.
Therefore, despite of the PHY906 could not directly protect the intestinal system from the damage caused by chemotherapy, but it does through the promotion of the rebirth of the ancestral source cells and inhibition of inflammation, intestinal cells to stimulate rehabilitation. This study emphasizes the value of traditional herbal treatment, explain the possible therapeutic mechanism to regulate a variety of biological activity by herbal multi recipe ingredients, may be able to provide the efficacy of conventional drugs can not be achieved.
Source:http://www.cospcn.com
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