The pathophysiology of dental pain is a complex system. The use of combination analgesics that act at multiple pain sites can improve dental pain relief.
Acetaminophen: Acetic acid and p-aminophenol, or APAP-commonly known as acetaminophen-is classified as a nonnarcotic pain reliever. Dentists generally use it for mild to moderate dental pain. It acts as both anti-pain and anti-fever. It has rapid painkiller action. Acetaminophen, unlike nonsteroidal anti-inflammatory drugs, or NSAIDs, has little anti-inflammatory action. It generally is safe for acute dental pain. At very high single doses it causes liver damages.
Acetaminophen's dose of 500-650 milligrams is good dental pain-reliever. However, such relief is brief, peaking one hour after administration. Significantly more dental pain relief can be provided by acetaminophen's dose of 1,000 mg. At this dosage, the maximal efficacy of acetaminophen is achieved and last up to four hours after administration. There is no more oral pain relief in dose higher than 1000 mg. Because of this "ceiling-dose" effect, acetaminophen is good shot-term reliever for mild dental pain.
NSAIDs: NSAIDs have been the traditional treatment for moderate dental pain and inflammation. NSAIDs such as ibuprofen, ketorolac, flurbiprofen, ketoprofen, diclofenac, aspirin and aspirin derivatives diminish local dental pain. Long-term use of NSAIDs, however, can gastrointestinal distress, bleeding, kidney damages, and cardiovascular problems. Also, NSAIDs have been shown to interact with several high blood pressure drugs, which may compromise blood pressure control. The most common short-term side effects of NSAID usage are upset stomach, diarrhea and abdominal pain.
NSAIDs generally require a higher dose to achieve maximum anti-inflammatory and anti-pain effect. Dosage of 800 mg three times per day may be needed for dental pain. The FDA-recommended daily dose is 2,400 mg. Studies has indicated that no more dental pain reliever is achieved with higher-than-the-recommended dosage. Comparing to acetaminophen, NSAID's are better pain killer, but they act slower and last about the same time (about 4 hours).
COX-2 NSAIDs: COX-2 NSAIDs were developed to limit NSAID's adverse effects. The two COX-2-selective inhibitors, celecoxib (Celebrex) and rofecoxib (Vioxx) are characterized by the following:
However, while COX-2 therapy may reduce the risk of GI ulcerations, recent evidence indicates that COX-2 therapy may not reduce the risk of cardiovascular complications (heart attacks). This is the reason why Vioxx is currently taken off the US market.
Common Traumatic Red Lesions in the Mouth (Part 2)
Mechanical trauma to the oral lining can produce a variety of clinical lesions. The purpuric macule is produced by a blunt traumatic insult to the skin.Common Traumatic Red Lesions in the Mouth (Part 1)
Mechanical trauma to your oral lining can produce a variety of clinical painful lesions such as the erythematous macules. Your dentist can help you to identify and remove the causative agent.Herbal Remedies: Friend or Foe?
Plants have been used for medicinal purposes since the Stone Age, so it is not surprising that a natural solution is appealing.