Effect of tretinoin on fibroblasts

Therefore, in recent years, many researchers use the fibroblast cell culture techniques to clarify the scar formation and regulation mechanism of scar formation. They have a study in fibroblast proliferation, collagen synthesis, cell activity and its influencing factors in controlled conditions. Tretinoin is a vitamin A-related drug with a wide range of pharmacological effects. The cosmetic raw material suppliers have received a clinical effect in the treatment of scars.

Scar formation is the result of wound healing. The pros and cons of wound healing is mainly depends on: the epithelial cell regeneration, migration and coverage; into the amount of fibroblast collagen synthesis, deposition and cross-linking. Fibroblasts can be divided into synthetic and contractile phenotype. In recent years: scar contracture tendency as a result of the contraction by fibroblasts. Therefore, if a certain drug is used in the process of wound healing, both to promote epithelial cell proliferation and differentiation, but also appropriate inhibition of fibroblast proliferation and activity will promote wound healing and prevent scar formation and contracture.

Fibroblast collagen synthesis in the cells and enhance the ability of fibroblasts to synthesize and secrete collagen or fibroblasts proliferation, may lead to the increase of the total amount of collagen. Is not difficult to imagine as fibroblast proliferation will inevitably lead to excessive production of collagen, if blocking the growth and proliferation of fibroblasts, it will prevent occurrence and development of scars.

A large number of cytological and biochemical studies have shown that collagen synthesis in fibroblasts in the rough endoplasmic reticulum, rough endoplasmic reticulum from the endoplasmic reticulum and ribosome formation of a complex functional units, cells for the biosynthesis of important bases. Has been confirmed into the rough surface of the fiber cells within the ER ribosome is the synthesis of collagen precursors place, and prove that this synthesis is not in a single ribosome, but in poly-ribosome. Therefore, attached to the ribosome on the endoplasmic reticulum, loss, and structural changes of the endoplasmic reticulum, of great significance for the synthesis of collagen.

The results show that, after using cheap tretinoin, fibroblast number is significantly reduced. The cell growth inhibition has a relationship with dose of retinoic acid. Using retinoic acid, a distinct change in cell morphology, the performance of the rough endoplasmic online ribosome degranulation depolymerization of endoplasmic reticulum expansion into the vesicles of varying sizes, vesicle contents are scarce or no content matter, while the cell surface and cells outside the fibrous material is small, surface processes also decreased. Description of the retinoic acid significantly affect the fiber cell endoplasmic reticulum and ribosomes, the role of protein synthesis, inhibition of collagen production, in addition to retinoic acid on mitochondrial obviously.

Mitochondria are the center of the cell energy metabolism, the synthesis reaction requires energy, through the via can affect a function of the fibroblast synthesis of collagen. Inferred that the mechanism may be the role of retinoic acid treatment of scars and inhibition of fibroblast growth and proliferation, inhibition into fibroblast DNA synthesis and affect collagen synthesis.

However, scar formation is extremely complex. In biological processes of retinoic acid, it still needs further study in biological activity. And the action mechanism of retinoic acid may focus on many aspects in treatment of scars. It is necessary to have further exploreation.Source:http://www.cosprm.com