AIDS is a contagious disease caused by the HIV. The therapy medicines zidovudine, dideoxy inosine can not completely kill the HIV virus. And they are toxic and expensive.
The extraction of anti-HIV drugs from traditional Chinese medicine become the focus of various countries researches in recent years.
The study results showed that resveratrol high dose group can inhibit a mouse model of splenomegaly (p <0.05) and thymus atrophy (p <0.01). It increases peripheral blood cd3 +, cd4 's +, cd8 + t lymphocyte subsets level, normal control group cd4 's + cell count of 47, model control group cd4' s + cell count of 15.53, resveratrol high dose group cd4 's + cell count of 30.96, resveratrol low dose group cd4' s + cell count of 22.44, alcohol group and model control group cd4 's + cell count differences were significant (p <0.01 or p <0.05). However, peripheral blood white blood cells and red blood cell count was no significant impact. The description of resveratrol in vivo anti-mouse HIV.
Resveratrol is a traditional Chinese medicine monomer. Previous studies found that it has antioxidant, free radical scavenging, anti-tumor, protect the cardiovascular, liver and other effects. In recent years, people also found it has antiviral activity, especially alcohol and its metabolites resveratrol glucoside in vitro studies have found that its anti-hiv activity and even enhance the role of the existing anti-hiv drugs, but its antiviral effect in vivo and the mechanisms have not been reported. Anti-hiv drugs in vivo studies using the maids mouse AIDS model is relatively simple and practical, for the researchers to introduce copy flv virus maids mouse model. Flv and hiv belong to the retroviridae, can simulate the symptoms characteristic of human AIDS, maids the model used for the screening evaluation of anti-HIV drugs, vaccines, such as clinical use of azt, ddi, dideoxy cytidine (ddc) and other drugs are flv model study in mice confirmed its efficacy and the model for the pathogenesis of study aids.
Experimental results show that mice with per kilogram of body weight that uses oral resveratrol 20 mg can inhibit flv caused by splenomegaly. The chia seed spleen is the main target organ of the virus. Flv mice infected with the spleen weight can be used to quantitate the viral load. So the drugs ability to suppress the virus and the spleen index become an intuitive and reliable indicator. Spleen has rich lymphocytes and macrophages. They are involved in the humoral immune response in the experiment. Resveratrol can inhibit splenomegaly showing that it not only has the in vivo anti-flv role but also can improve the role of the humoral immune function. From the experimental results of the immunological parameters, the effect of resveratrol on cellular immune regulation, immune dysfunction caused by the retrovirus is particularly significant. It shows that the drug can enhance immune function, inhibit the immune deficiency caused by the flv. It is a better immunomodulator. Scientists believe that resveratrol can treat mice with AIDS. But the specific mechanism needs further study.Source:http://www.cospcn.com
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