As pharmaceutical raw materials, capsaicin has the effect of desensitization, can damage the primary feeling into C-fiber nerves, so capsaicin has been used to treat a variety of neuropathic pain and related symptoms.
Which the more mature is that the capsaicin cream use to treat skin pain, itching, such as postherpetic neuralgia, diabetic neuralgia, trigeminal neuralgia, efficacy optimistic. Treatment of neurogenic bladder excesses and hyperalgesia efficacy of the capsaicin solution intravesical infusion been clearly demonstrated in clinical trials in 200 patients. Capsaicin make the density of nerve fibers decreasing in the patient's bladder, so that obtain a longer period of relieving.
Capsaicin acts on the skin peripheral nerve endings, a burning feeling, and caused the local area congestion, even neurogenic inflammatory response. Capsaicin applied to the mucosa causing sneezing, nasal congestion, cough, mucus secretion, watery eyes, bronchoconstriction, breathing difficulties and other symptoms. Chili strong irritant inhalation, capsaicin oil is made from tear gas, spray cans sold as self-defense weapons in some national markets. Capsaicin irritant limit its clinical application. Research directions in clinical application, clear the adverse of capsaicin and retain of its desensitization analgesic efficacy is the research objectives of the clinical application of capsaicin. The following 3 aspects is the most promising breakthrough in direction.
In combination with other drugs, lidocaine and capsaicin combined to use will cause synergistic retarding effect. Lidocaine can block the nerve reflex arc path. Thus easing the capsaicin which can weaken hot allergy symptoms caused by capsaicin. In the study of oral sensitivity to capsaicin, the scientists found that first coated with menthol in a short time (a few minutes), the oral is insensitive to capsaicin.
Change the mode of taking medicine, in addition to the surface of the skin and mucous membranes application, you can try to change the route of taking medicine to avoid the side effects of capsaicin stimulating peripheral nerve endings. Pepper receptor present in the dorsal root ganglia, trigeminal ganglion sensory ganglion cells, the perineurium or ganglia direct application of the theory is valid. The scientists applied capsaicin on nerve bundles membrane selectively block C-wave complex potential of the incoming branch of the superior laryngeal nerve, A wave has no effect. Capsaicin microinjection into the rat arc the beam nuclei caused bradypnea. Inject capsaicin to rat gastrocnemius, halibut intramuscular, nerve reflex is suppressed. Select the capsaicin derivatives the gum resin toxin is one of the very promising capsaicin substitute. Perfusion treatment of bladder detrusor excesses the gum resin toxin bladder pain, have the similar effect with pepper, but no local irritation.
In addition, with the further study of VR1 receptors and the gene mature, people can through VR1 receptors to synthetize VR1 excited or antagonists, or even the synthetic VR1 receptor regulation from the gene level expression, one day, humans will reveal all the secrets about the relationship of capsaicin and pain.
Source:http://www.cospcn.com
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