About drug absorption - the process of it and how it affects the release of new drugs to the market
In pharmacology, drug absorption refers to the process, wherein the drug moves from the muscle or digestive tube into the body towards the cardiovascular system. In short, drug absorption is the movement of drug into the blood vessels. This movement involves various phases.
The drug absorption process starts when a patient consumes any medicine, be it in the form of a capsule or tablet.
In some drug delivery techniques such as the intravenous therapy, enteral nutrition and intramuscular injection, drug absorption is higher with 100% bioavailability.
Proper drug absorption is one of the key factors in determining the success of treatment in a patient. However, it is unknown as what kind of in-vitro drug release requisites are required to ensure that the drug absorption has no substantial effects on the in-vivo bioavailability.
Despite of recent developments in drug absorption modeling and simulation, the relationship between in-vitro drug release and in-vivo absorption process is still unclear. The primary aim of drug development is to discover the drugs, which are more effective to cure symptoms of illness. Drug development also has to meet the regulations set by the authorities and bureaus, who license drugs.
The means to deliver a pharmaceutical substance into human beings or animals is mainly referred to as the drug delivery system. The basic modes of drug delivery are nasal, oral and rectal.
Recent innovations in the area of drug delivery systems include, advance delivery systems, where drugs are activated exactly in the targeted areas of the body. Another common misconception is that permeability and absorption are distinct in terms of drug delivery techniques. Nevertheless, they are key properties of drug molecules and originate from some structural representation of the drug.
Drug absorption is a complex process, which is dependent on drug properties such as formulation factors, solubility, physiological variables, permeability, pH levels, intestinal motility, and mucosal enzymology.
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