There's more evidence that people with type 2 diabetes may have an increased risk of bladder cancer, and taking the diabetes drug generic Actos cheap may raise that risk even higher.
There's more evidence that people with type 2 diabetes may have an increased risk of bladder cancer, and taking the diabetes drug generic Actos cheap may raise that risk even higher.
"The evidence suggests that this drug is associated with about a 22 percent increased risk of bladder cancer," said study senior author Jeffrey A. Johnson, the Canada Research Chair in Diabetes Health Outcomes at the University of Alberta School of Public Health, in Canada.
Johnson said it's not clear yet how Actos might raise the risk of bladder cancer, but he said some animal studies suggested that the drug could cause crystals to form that irritate the bladder, which could potentially play a role in the development of bladder cancer.
Johnson added that it's important to keep in mind that bladder cancer is a relatively rare cancer, and even with the increased risk, any one person's risk of bladder cancer "is pretty small."
People with type 2 diabetes have a 40 percent increased risk of developing bladder cancer, according to background information in the current analysis. This increased risk is believed to be associated with high levels of insulin found in people with type 2 diabetes. Insulin is a hormone that helps the body turn carbohydrates from food into sugar (glucose) that can be used for fuel. Insulin is also a growth hormone, and cancer cells have insulin receptors on them, which means they can use insulin to grow, according to Johnson.
"The bladder cancer risk appears to be real, but is pretty small. If you're not at risk of bladder cancer in the first place, the benefits of pioglitazone [Actos] may outweigh the potential risk," Johnson said.
Commenting on the study findings, Dr. Joel Zonszein, director of the clinical diabetes center at Montefiore Medical Center in New York City, said: "Complications of diabetes can be very bad, and some patients do very well on Actos."
He added that he sometimes uses this medication in combination with other diabetes drugs. "Bladder cancer tends to be rare, but it's much more common in men and it's also more common in smokers, so I don't put elderly male smokers on Actos. But, for other patients who have a low risk of bladder cancer, I may use Actos. We just have to be vigilant when we prescribe medications."
Zonszein said it's also important to remember that people with type 2 diabetes already have an elevated risk of bladder cancer, and they often don't start diabetes medications until they are much older, often obese and have had the disease for awhile, so "there may be a population bias" in the studies. To buy Actos Canada has to be checked and reviewed by doctors for safety.
Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger).
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