Hair loss refers to the phenomenon of losing hair. Normal shedding hair is the hair in the catagen and new entrants with a dynamic equilibrium. It can maintain a normal number of hairs and that is the normal physiological alopecia. Pathological alopecia refers to abnormal or excessive hair loss with many reasons.
The main symptoms of hair loss are greasy hair. It is lacking of luster, pale yellow scales fixed impunity, or gray scales flying consciously itching if, on the other hand, male hair loss, mainly the front and top of the head, forehead, hairline and sideburns moved up front and the top of the sparse hair, yellow, soft, and an end to the amount at the top of a bare or some hairs. Female hair loss is at the top of the head, the hair becomes sparse, but not completely off.
For western medicine to treat hair loss, in addition to use hair transplant technology, is they also use two combination drugs in treatments: finasteride (oral), and minoxidil seoul (topical). The majority of the finasteride drug 5±-reductase inhibitors, lower testosterone serum and scalp dihydrotestosterone levels after oral administration, 60-70%, reducing the amount of testosterone in dihydrotestosterone in the hair follicle, preventing hair follicle becomes smaller, reversible. The male hormone hair loss patients have hair loss plot. Its use of daily oral administration of 1mg, testosterone transformation into dihydro-testosterone, resulting in the containing type a 5± reductase, this enzyme makes male patients with alopecia scalp hair follicles change, alopecia double hydrogen testosterone. So the hereditary seborrheic alopecia real behind the culprit is this 5± reductase. People who has congenital absence of the type a 5± reductase will not suffer from male baldness.
For security of long-term treatment with finasteride, some hair loss patients have following drug-related adverse events after use according reminds from cosmetic raw material suppliers: loss of libido, impotence and ejaculation decreased. Continuous application of non-patients with hair loss finasteride for one year, 547 cases, 239 cases of adverse reactions due to drug-related sexual function and stop the medication. The majority of these side effects continue treatment gradually disappeared, subsided after a few months or weeks after discontinuation of treatment adverse reflection of the points mentioned above.
The minoxidil prolong the hair growth long term, so that miniaturization of the hair follicle increases. In the hair follicles in vitro, by adding minoxidil can increase the cultivation time of growth of hair follicles. The hair follicle hepatocyte growth factor and vascular endothelial cell growth factor is the dermal papilla of the two major growth factor, an important role in the regulation of hair growth cycle. Minoxidil can effectively increase the dermal papilla cells of vascular endothelial growth factor, minoxidil through the stimulation of cytokines to maintain the growth of hair follicles and dermal papilla blood vessel formation and function, and thus play an important role in the treatment of hair loss.
The main side effect of topical minoxidil is irritant reaction. The applying site is dry, scaling, itching and redness. The incidence of 2% solution is about 7%. For 5% solution, the high incidence is higher that 2% solution and it is about 20%. These side reactions relate to the concentration of propylene glycol. The propylene glycol concentration of 5% minoxidil is much higher. The report shows using high concentrations of minoxidil will get allergic contact dermatitis or photo-allergic contact dermatitis. Other side effect of skin is the increasing of body hair, but there are fewer men who have the side effect. Either 5% or 2% minoxidil solution, if the daily application is about 2 times and 1mL every time, it generally does not cause changes in blood pressure, pulse or weight.Source:http://www.cosprm.com
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