Increasingly popular antidepressant herb St. John's wort can reduce the efficacy of anticancer drug irinotecan. In the cancer patients (sarcoma, colorectal cancer and lung cancer patients) who use the irinotecan and St. John's wort at the same tome,
The content of irinotecan active ingredient in their bodies in 42% less than the patients who take irinotecan only.he study found that, while taking irinotecan St. John's wort will reduce the side effects of irinotecan (effect of irinotecan is to inhibit the growth of bone marrow cells and increase patients' susceptibility to infection). Irinotecan just entering the human body and there is no activity in the organi irinotecan zation carboxylesterase metabolism to SN-38 after the performance of anti-cancer activity. In the meantime, however, certain enzymes in the liver will also participate in changing the chemical properties of irinotecan, thus weakening its ability to destroy tumor cells, while St John's wort can increase the expression levels of these enzymes (e.g. CYP3A4), which St. John's wort to reduce the reasons for the efficacy of irinotecan in Iraq.
Also likely to be CYP3A4 changing the chemical characteristics of chemotherapeutic drugs to the St. John's Wort to reduce its efficacy, such as taxol, taxotere with tamoxifen. Garlic, ginkgo, ginseng, and kava plant can affect the level of CYP3A4 expression may affect the efficacy of anticancer drugs.
Although St. John's wort can help cancer patients, anti-depressants and to reduce the side effects of the chemotherapy drug irinotecan, but it also weakens the efficacy of pharmaceutical raw materials irinotecan treatment of cancer. The study found that St. John's wort can change irinotecan metabolism and toxicity in the human body, not yet fully understood before St. John's wort is how to affect the antitumor activity of irinotecan, these two drugs are not suitable joint for the treatment of cancer. Physicians in medication for patients, but also should ask whether the patient is taking these plants clearly.
The study suggests that cancer patients are most likely to accept alternative therapies. In view of the current study, cancer patients need special care in complementary/ alternative medical. That is because they may not be safe.
Source: http://www.cospcn.com
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