the protective effect of resveratrol on cardiovascular system is becoming a hot spot.
Modern pharmacological studies have shown that resveratrol has multiple beneficial effects, such as the regulation of lipid metabolism, inhibition of LDL oxidation and platelet aggregation, cardiovascular protection, ischemic injury, anti-inflammatory and anti-tumor.
Resveratrol can inhibit LDL oxidation and protect endothelial cells of oxidized LDL injury. It plays a protective role in early atherosclerosis. The study confirmed that resveratrol can effectively remove the hydroxyl oxygen, peroxides and metal free radicals and protect the lipid peroxidation and DNA damage caused by oxygen free radicals. Resveratrol can weaken the production of oxidized low-density lipoprotein-induced cytotoxicity and reactive oxygen free radicals, reduce the savings of intracellular calcium, inhibition of cytochrome C release and apoptotic protein caspase 3 activity, thereby protecting oxLDL injury endothelial cells.
It is found that resveratrol can inhibit lipopolysaccharide-induced expression of VCAM-1, and can prevent monocyte adhesion to endothelial cells. Resveratrol diminished STAT3 phosphorylation inhibition of interleukin-induced ICAM-1 gene expression. Studies have shown that resveratrol and glutathione have inhibitions in transplanting human saphenous vein endothelial VCAM-1 and ICAM-1 expression, and prevent neutrophil adhesion to endothelial cells.
Advanced glycation end products can contribute to stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats, vascular smooth muscle cell proliferation and a concentration and time dependent manner, while resveratrol can significantly inhibit the SHRSP of VSMC proliferation, as well as DNA synthesis and secondary aminoacyl-hydroxylase activity. Resveratrol can inhibit the expression of transforming growth factor gene.
Resveratrol is a phytoestrogen, can combine with estrogen receptor in the human body and play estrogen-like effects, so for the cardiovascular system may have estrogen-like protective effect. Resveratrol may be associated with the ER signal rapid activation of the anti-atherosclerotic role of resveratrol promote eNOS gene expression can not be blocked by the ER antagonist, on isolated pig coronary vasodilation has not been the ER antagonist impact. Resveratrol is mainly in the fast activated by non-genetic means ER play an estrogen-like protective effect.
Resveratrol and its derivatives are a class of plant polyphenols studied by many scientists in recent years. Their anti-atherosclerotic role has gradually become a hot topic. But mechanisms of chia seed and it are far from clear, such as the effect of resveratrol on the ion channels, as well as the exact signal transduction pathway and how does the relationship of dose against atherosclerosis. They all need further study. With in-depth study of resveratrol and its derivatives. It can be expected to open up new ideas for drug development in the prevention and treatment of atherosclerotic disease.Source:http://www.cospcn.com
The application of tungsten in various industries
Steel Industry Most of tungsten applied in the production of special steels. The widely used high-speed steel was containing 9-24% of tungsten, 3.8-4.6% of chromium, 1-5% of vanadium, 4-7% of cobalt, 0.7-1.5% of carbon.
Magic effects of coconut oil
According to records, coconut oil can be regarded as the nobility of skin care plant extracts. It was rich in exotic tension of tropical plants, which can enhance the contractile force of the pores, perfectly beautify and nourish the skin.
Exploring the Potentials of Nano-Aluminum Powder
Nano-aluminum powder, a material with remarkable properties due to its minuscule particle size, is revolutionizing various industries with its high reactivity and large specific surface area. Unlike its bulk counterpart, nano-aluminum powder begins to oxidize at a lower temperature of 550°C, compared to the 950°C oxidation point of ordinary aluminum. This lower ignition energy and full combustion without apparent cohesion make it a superior choice for applications requiring high energy and efficiency. The unique characteristics of nano-aluminum powder, such as faster burning rates and greater heat release, are largely influenced by its synthesis method, which determines its particle size, surface area, and shape.
